RESEARCH
Supporting research that advances our understanding of Diamond Blackfan Anemia Syndrome.
DBA Canada is pleased to have assisted in funding important research in Diamond Blackfan Anemia Syndrome since 2009
We have most notably assisted in funding the following research projects and will continue to support innovative research that advances our understand of Diamond Blackfan Anemia Syndrome and improves outcomes for those living with DBAS.
Dr. Senthil Bhooplan's project entitled "preclinical development of lentiviral vector gene therapy for Diamond Blackfan Anemia.
Dr. Grant Rowe of Boston Children’s Hospital received a grant for this project entitled, Replication stress in Diamond-Blackfan anemia.
Dr. Agnes Czechowicz and Dr. Kathleen Sakamoto of Stanford University for their project entitled, Development of mobilization-based conditioning for hematopoietic stem cell transplantation in DBA. This research could guide future gene therapy approaches and potentially reduce or eliminate the need for toxic chemotherapy conditioning.
Dr. Lucy Godley of Northwestern University, Dr. Adrianna Vlachos of Johns Hopkins All Children’s Hospital, and Dr. Deena Iskander of Imperial College London for their collaborative grant entitled, Frequency of germline cancer risk alleles in DBA patients diagnosed with cancer.
Paola Quarello, M.D., PhD. of University of Turino, Italy for her project entitled, A Novel DNA Methylation Episignature for the Diagnosis of Diamond-Blackfan Anemia focuses on the molecular diagnosis of Diamond Blackfan Anemia Syndrome (DBAS), which remains unresolved in about 20-30% of cases despite current genetic testing strategies.
Dr. Sharon Singh of the University of Michigan for her research in metabolic strategies to target defective erythropoiesis in DBA syndrome.
Johan Flygare M.D., Ph.D. of Lund University, Sweden for his research project entitled, “Advancing Gene Therapy for Patients with Diamond Blackfan Anemia.
Dr. Senthil Bhooplan's project entitled "preclinical development of lentiviral vector gene therapy for Diamond Blackfan Anemia.
Dr. Gleizes and Dr. Yu's Work on Gene Discovery.
Dr. Laura Paulette Fernandez project studying the use of brand chain amino acids to treat DBA.
Dr. Johan Flygare's project entitled "Targeted Corticosteroid Therapy for DBA".
Dr. Vijay G. Sankaran, M.D., Ph.D., Harvard Medical School, Broad Institute of MIT and Harvard, Boston Children’s Hospital, Boston, MA for the project, "Dissecting the genetic architecture of Diamond Blackfan anemia" The goal of this proposal is to mine whole exome sequencing data gathered through a collaboration with the Broad Institute at MIT/Harvard to identify novel genes responsible for DBA.